How MPNST genomic alterations affect therapy resistance is currently unclear
How MPNST genomic alterations affect therapy resistance is currently unclear. models recapitulated an MET-addicted state (NF1-MET), P53 mutation (NF1-P53), and HGF overexpression (NF1). Following perturbation with the drug, we observed broad and redundant kinome adaptations that extended well beyond canonical RAS/ERK or PI3K/AKT/mTOR signaling. MET and MEK inhibition were both associated with an initial inflammatory … Continue reading How MPNST genomic alterations affect therapy resistance is currently unclear
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